Sigma offers an extensive collection of over 4,000 small molecule tools to modulate target activity, with new small molecules being added every week. Please review our featured new products below, or browse all new products using our variety of search features.

 

Selective GPR68 positive allosteric modulator – Ogerin (SML1482) 
Selective positive allosteric modulator of GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1).
 

Negative control for ogerin – Ogerin negative control (SML1483) 
Structurally similar analog of ogerin; inactive and serves as a negative control.
 

Selective PPARδ agonist – GW501516 (SML1491) 
PPARδ agonist with high affinity and potency, and >1000 fold selectivity over PPARα and PPARγ.
 

mGluR4 positive allosteric modulator (PAM) – PHCCC (SML1432)) 
Potent group I metabotropic glutamate receptor antagonist.
 

Prostaglandin synthesis inhibitor – Metamizole (Dipyrone) (SML1488) 
Inhibits prostaglandin synthesis in periphery and CNS; potent analgesic and antipyretic.
 

Akt/PKB inhibitor – API-1 (SML1342) Inhibits all three members of the family Akt1/PKBa, Akt2/PKBb and Akt3/PKBg.

 

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Source: www.sigmaaldrich.com